Newborn screening offers the potential for the early asymptomatic detection of serious or life threatening conditions. Pioneered in the 1960s by Dr Robert Guthrieit has since been widely adopted throughout the world. Now many countries screen for up to 50 disorders shortly after birth and it is estimated that more than 30,000 children each year benefit from this life changing intervention. While these achievements have been recognised as a significant public health success, both challenges and opportunities lie ahead. In this webinar we will address the opportunities provided by the recent IFCC task force to expand newborn into low and middle income countries where this is not currently available. This will be exemplified by the successful development of well organized national newborn screening in the Philippines. Recently of course the genetics revolution has begun to affect all aspects of diagnosis and treatment and this is certainly true of newborn screening where genomics has begun to be used extensively as an adjunct to traditional biochemical means of detection. There are also plans to use whole genome sequencing as a first line testto unlock the detection of a much greater number of conditions and these potential uses of genetic testing shortly after birth will be explored. The method of sample collection first described by Dr Guthrie in the1960s using a drop of blood collected onto filter paper has stood the test of time but there are practical aspects to the way in which these samples are collected, transported and stored and in this webinar we will examine some of these practical aspects of newborn screening.