D-Dimers is a determination that has several applications. It's classic use is to rule out thrombosis and can be also used to predict its recurrence. D-Dimer (DD) is a molecule that comes from the degradation of stabilized fibrin. Its presence indicates fibrinolysis secondary to the formation of a fibrin clot. Therefore, it constitutes a specific marker of fibrinolytic activity in processes that produce excessive fibrin formation, even without being thrombotic. In relation to cancer, it can be used to exclude thrombosis, also as predictor of venous thromboembolism, as prognosis of recurrence of thrombosis, and as prognostic factor for the disease.